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Polynucleotides in Barcelona
They don't fill, they don't rejuvenate by volume: they regenerate skin from within. Polynucleotides are the most elegant technique for improving quality, tone and density without changing anatomy.
What they are and when they make sense
Polynucleotides are highly purified DNA fragments of marine origin — salmon or trout. Injected into the skin, they stimulate fibroblasts, improve intracellular hydration, increase own collagen synthesis and exert an antioxidant and anti-inflammatory effect.
They make sense in skin with loss of quality, in the eye contour with vascular or pigmentary under-eye, in neck and décolletage with incipient laxity, and in patients seeking bioregeneration without volume. Also an excellent indication in patients who reject fillers or have had negative previous experiences.
My approach
I work with Plinest and Newest — European reference brands with the highest documented purity on the market. Purity matters: biological effect depends on the quality of the molecule, not just its presence.
Polynucleotide is rarely a standalone treatment. It usually integrates into a broader plan: alongside toxin to relax expression pattern, with biostimulators for density, or with laser for colour and texture. Combination makes sense when each technique brings what others cannot.
What the process looks like
In consultation I assess skin type, ageing pattern and goal. I propose the number of sessions — usually 3 or 4 — and interval (every 2–3 weeks).
Session lasts 30 minutes. Injection with very fine needle or mesotherapy gun, in multiple superficial micro-pricks. Topical anaesthetic in sensitive areas like eye contour. Discomfort is mild and you can resume normal life the same day.
What to expect
Change is progressive and cumulative. From the 2nd session you will notice more luminous, hydrated skin. From the 3rd–4th session improvement in texture, firmness and overall quality is visible.
Result lasts 6 to 12 months depending on age, baseline skin quality and habits. Periodic maintenance is recommended. Polynucleotide adds no volume and does not change shape. It gives skin: that is its function and its limit, and that is exactly its advantage.
When I DO NOT recommend polynucleotides
When the patient's demand is volume or structural correction. Here the correct treatment is hyaluronic acid or dense biostimulation; polynucleotide does not offer what you seek.
When the patient seeks an immediate visible change in a single session. Polynucleotides require several sessions and effect is gradual. In patients with documented fish protein allergy, pregnancy, breastfeeding or active infection in the target area.
Frequently asked questions
What exactly are polynucleotides?
Highly purified DNA fragments of marine origin (salmon or trout) that, injected into the skin, stimulate cellular regeneration, improve hydration and increase own collagen synthesis.
How many polynucleotide sessions are needed?
Between 3 and 4 sessions spaced every 2–3 weeks for a complete cycle. Maintenance is usually one session every 4–6 months.
How do polynucleotides differ from hyaluronic acid?
Hyaluronic acid provides volume or immediate structural hydration; polynucleotides regenerate skin from within, without changing anatomy. They are complementary techniques, not substitutes.
Do polynucleotides work for under-eyes?
Yes, especially in vascular under-eyes or with poor-quality skin, where hyaluronic acid is not indicated. They improve colour, texture and density of the eye contour.
Regenerative medicine
Regeneration of the dermal structure, working the skin from within, across several levels.
Biostimulation
Stimulation of your own collagen to improve skin quality, firmness and density over the medium term.
Facial mesotherapy
Deep hydration and luminosity with microinjections of active ingredients, session by session.
Every treatment begins with a good decision.
Book your medical assessment and we will discuss together whether this treatment makes sense for you — or whether another option is a better fit for your case.